Police are appealing for public assistance to help locate missing 45-year-old Bundoora woman Moira Coulson.
Ms Coulson was last seen in Lawrence Court, Bundoora about on Friday 20 November.
Police have concerns for her welfare due to a medical condition.
Moira is known to frequent the Melbourne CBD and Frankston areas, and travels on buses and trains.
Investigators have released an image of Moira in the hope that someone may recognise her or have information regarding her whereabouts.
Anyone who sights Moira or has information is urged to contact Mill Park Police Station on (03) 9407 3333.