Police are appealing for public assistance to help locate missing man Christian Soto-Santander.
The 31-year-old Cranbourne West man was last seen this morning on the Princes Highway in Noble Park.
Police have significant concerns for his welfare and believe he may have suffered a serious injury.
He is described as 180cm tall with a medium build, black hair, brown eyes and a fair complexion.
Anyone with information about Christian is asked to contact the Dandenong Police Station on (03) 9767 7444 or Crime Stoppers on 1800 333 000.