The 13-year-old was last seen at an address on Moreton Street, Frankston North yesterday about 12:15pm.
Police and family have concerns for Chloe due to her young age.
Chloe is described as being 162cm tall, of slim build with hazel eyes and shoulder-length brown hair with blonde tips.
Investigators have released an image of Chloe in the hope that someone may have information on her current whereabouts.
Anyone who sees Chloe is urged to contact Frankston Police Station on (03) 9784 5555.