Police were patrolling in Thomastown when they observed an allegedly stolen grey Subaru bearing no plates travelling at 160km/h on Edgars Road about 2am.
Officers followed the car towards Reservoir but lost sight of the stolen car as the driver had no headlights on.
Shortly after, the driver encountered a vehicle checkpoint on Mahoneys Road and allegedly attempted to perform a U-turn but became stuck on a median strip.
Officers approached the car and arrested a 34-year-old man who was then transported to hospital under police guard.
The Lalor man is expected to be charged with theft of a motor vehicle, theft from motor vehicle and reckless conduct endangering life.