The 16-year-old was last seen at a Kylie Street property about 5:30pm on Monday 7 September and has not been seen since.
Police and family hold concerns for his welfare due to his age and the length of time he has been missing.
Jayme is described as having short brown hair and is unshaven.
He is believed to be wearing a grey hooded top and black pants.
Jayme is known to frequent the Hume area and Melbourne CBD.
Investigators have released an image of Jayme in the hope someone recognises him and is able to provide information on his whereabouts.
Anyone with information is urged to call Broadmeadows Police Station on 9302 8222.