The solo rider caught the attention of police on Camp Road after it was seen driving erratically about 8pm on Sunday evening.
Police attempted to intercept rider but didn’t pursue after the motorcyclist speed off.
Shortly after it’s believed the rider travelled through a red light at the intersection of Camp Road and Northcorp Boulevard and collided with a truck.
The 24-year-old rider from Broadmeadows received life-threatening injuries and was conveyed to hospital.
Major Collision Investigation Unit detectives worked throughout the night processing the scene and Professional Standards Command has been notified.